NACE

Non-invasive prenatal test

Non-invasive prenatal screening which avoids unnecessary amniocentesis

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Overview

NACE® is a non-invasive prenatal screening that detects the most frequent chromosomal abnormalities.

It detects abnormalities in chromosomes such as:

  • 21 - Down syndrome
  • 18 - Edwards syndrome
  • 13 - Patau syndrome
  • It also detects the most common anomalies in the sexual chromosomes (X and Y), except for twin gestations.

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Coverage of the NACE test for single pregnancies (as a percentage of detected chromosomal abnormalities*):

Coverage of the NACE test for single pregnancies ordered by they importance*

Benefits

  • More reliable than 1st trimester combined screening
  • Allows the testing in twin pregnancies*, vanished twins and egg donation
  • For women of any age, regardless of body mass index or ethnicity
  • Can give results with foetal fraction under 4%
  • NACE reduces unnecessary amniocentesis
  • Highest informativeness rate in the market: we obtain results for 99.9% of the analyzed samples
  • NACE® Extended 24 incorporates the detection of all 24 chromosomes, and identifies five microdeletions, which are associated with major genetic syndromes

*Aneuploidies for sex chromosomes not analyzed. Presence or absence of Y chromosome informed.

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Indications

Scientific societies support the use of NACE test for all pregnant women(*).

NACE is especially recommended for women with:

  • An abnormal result in their first trimester screen
  • A previous Down syndrome pregnancy
  • A suspicious ultrasound finding

More Info

 

*Gregg AR, Skotko BG, Benkendorf JL, et al. : Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics. Genet Med. 2016;18(10):1056–65. 10.1038/gim.2016.97

Why a non-invasive prenatal test?

When only a biochemical screening is performed:

Unnecessary concern

Out of every 20 women who test positive for Down syndrome, one will be carrying an unaffected child.

False sense of security

Out of every 20 women carrying a baby with Down syndrome, 3 will test negative by biochemical screening.

Methodology

What happens in the case of a positive result

  • Genetic counseling post-test
  • Comprehensive ultrasound examination
  • Results confirmation by genetic diagnostic testing (ammiocentesis or CVS).

Depending on the screening results, diagnostic testing approach should be karyotype and:

  • Rapid prenatal testing by qfPCR
  • Rapid prenatal testing by FISH
  • Microarrays for prenatal diagnosis

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