The endometrium matters

A new dimension of endometrial health to improve the reproductive prognosis of your patients

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Overview

Since 2014, IGENOMIX has been conducting a deep line of research to understand the endometrial factor in recurrent implantation failure patients.

Our recent publications in the American Journal of Obstetrics and Gynecology (AJOG) demonstrate a new dimension of endometrial health that can improve your patient's reproductive prognosis.

Dysbiosis of the uterine cavity has been associated with poor reproductive outcomes in IVF patients, suggesting that pathogenic deviations of the Lactobacillus endometrial content could play a role in infertility (Moreno et al., 2016).

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According to internal data and several independent clinical studies, selecting normal embryos might increase the pregnancy possibilities after transfer.

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Benefits:

  • Reduced miscarriage rates.
  • Higher pregnancy rates per transfer.
  • Fewer cycles of IVF treatment needed (less time and money).
  • Greater chance of having a healthy child.
  • Fewer wasted transfers (implantation failure).

The PGS increases the possibility of having a healthy baby, as it allows chromosomally normal embryos to be identified.

The mean theoretical time to achieve a LB (weeks) decreases from 14.9 to 7.7 weeks with PGS (1)

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PGS helps to avoid repeating cycles of assisted reproduction and can help to reduce the number of multiple pregnancies performing by supporting single embryo transfer

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ERA

ERA (Endometrial Receptivity Analysis) evaluates the status of the woman's endometrial receptivity to help prevent implantation failure, by finding the optimal time for embryo transfer.

The ERA test resulted in a 73% pregnancy rate in patients with implantation failure.

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EMMA

EMMA (Endometrial Microbiome Metagenomic Analysis) is a screening test to evaluate the endometrium at the microbiological level; improving clinical management of infertile patients.

By analyzing the endometrial microbiome, EMMA determines whether the uterine microbial environment is optimal for embryo implantation,  in patients both with and without recurrent implantation failure.

EMMA provides information about the ten most abundant bacteria in the endometrium, recommending embryo transfer or appropriate treatment, depending on results. EMMA also includes the analysis of chronic endometritis provided by ALICE. 

Moreno et al. Am J Obstet Gynecol, 2016

More info
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An endometrium is receptive when it is ready for embryo implantation. This occurs around days 19-21 in each menstrual cycle of a fertile woman. This period of receptivity is what we call the window of implantation.

The lack of synchronisation between the embryo ready to be implanted and endometrial receptivity is one of the causes of recurring implantation failure. This is why it is imperative to assess the endometrium in order to determine the optimal day for embryo transfer.

The ERA test requires an endometrial biopsy that should be carried out on day LH+7 (natural cycle) or day P+5 (HRT cycle). This biopsy is quickly and easily taken by a gynaecologist in their consultation room and sent to Igenomix for testing
The ERA test analyses the expression levels of 236 genes linked to the status of endometrial receptivity, using RNA sequencing taken from the endometrial tissue.

Following the analysis, a specific computational predictor classifies the samples according to their expression profile as Receptive or Non-Receptive.

 

The Endometrial Receptivity Anaysis (ERA®) has been designed, developed and patented by IGENOMIX (PCT/ES2009/000386)..

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ALICE

ALICE (Analysis of Infectious Chronic Endometritis) is a diagnostic test to detect the bacteria causing chronic endometritis, a condition that is associated with infertility.

Independent studies show that this condition affects up to 30% of infertile patients, and in cases of repeated implantation failure or recurrent pregnancy loss, this can rise to 66%*.

ALICE detects the eight most common bacteria causing the disease and helps clinicians to recommend appropriate antibiotic and probiotic treatments.

*Cicinelli et al. Reprod Sci 2014; 21(5):640-7 and Cicinelli et al. Hum Reprod. 2015; 30(2):323-30.

More info

References

Scientific publications and documents.

Endometrium Specialist Brochure

Specialist Brochure

Manual

Manual

Infographic

Our results

Our reliable and approachable team of experts is ready to guide clinicians and patients throughout the entire process. We are proud to deliver high quality results for every test, every day.

20%

    of infertility is caused by     

 the endometrial factor

30%

of infertile women

have pathogenic

bacteria

+20

years' experience
in genetics

14

laboratories worldwide

1: Rubio et al: In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study. Fertil Steril. 2017 May;107(5):1122-1129.

2: Rubio et al: Preimplantation genetic screening using fluorescence in situ hybridization inpatients with repetitive implantation failure and advanced maternal age: two randomized trials. Fertil Steril. 2013 Apr;99(5):1400-7

3: What a difference two days make: “personalized” embryo transfer (pET) paradigm: a case report and pilot study. Hum Reprod. 2014 Jun;29(6):1244-7. doi: 10.1093/humrep/deu070. Epub 2014 Apr 15. PubMed PMID: 24737781. Ruiz-Alonso M, Galindo N, Pellicer A, Simón C.

4: A Genomic Diagnostic Tool for Human Endometrial Receptivity based on the Transcriptomic Signature. Fertil Steril.2011. 95(1)pp: 50-60, 60.e1-15 Díaz-Ginemo P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, Simón C

5: The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.. Fertil Steril. 2013 Sep;100(3):818-24. doi: 10.1016/j.fertnstert.2013.05.004. Epub 2013 Jun 4.PubMed [journal]PMID:23756099 Ruiz-Alonso M, Blesa D, Díaz-Gimeno P, Gómez E, Fernández-Sánchez M, Carranza F, Carrera J, Vilella F, Pellicer A, Simón C.

6: The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity.. Fertil Steril. 2013 Feb;99(2):508-17. doi: 10.1016/j.fertnstert.2012.09.046. Epub 2012 Oct 23 Díaz-Gimeno P, Ruiz-Alonso M, Blesa D, Bosch N, Martínez-Conejero JA, Alamá P, Garrido N, Pellicer A, Simón C.

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