SAT Sperm aneuploidy test

What is SAT?
Benefits
Indications

What is SAT test?

The Sperm Aneuploidy Test (SAT) is a test to study the genetic factor of male infertility.

It allows for the evaluation of the presence of an abnormal number of chromosomes (aneuploidy and diploidy) in the sperm.

The chromosomes 13, 18, 21, X and Y, are most frequently implicated in spontaneous miscarriages and affected offspring with chromosomal abnormalities. In SAT, these chromosomes are analysed by fluorescence in situ hybridization (FISH).

Why should use SAT test?

An increase of sperm chromosomal abnormalities affects your reproductive journey at three levels:

EMBRYO LEVEL:

Spermatozoa with sex chromosome abnormalities results in aneuploid embryos
Diploid sperm results in triploid embryos

Rodrigo et al., 2010.

Click me! Click me! Click me!

PREGNANCY LEVEL:

An altered SAT decreases pregnancy rate after ICSI and increases miscarriage rate

Rubio et al., 2001.

OFFSPRING LEVEL:

Sperm chromosomal abnormalities increase the risk of abnormal offspring for the chromosomes affected in the sperm (Down, Klinefelter or Turner’s Syndromes)

Who should use SAT test?

Men with a low sperm concentration, who typically have a higher incidence of sperm chromosome abnormalities
Couples who have suffered recurrent miscarriage of unknown origin
Couples who have experienced repeated implantation failure
Couples with a previous pregnancy with a chromosomal abnormality

Test limitations

This technique allows the detection of aneuploidy only for the chromosomes included in the test (13, 18, 21, X and Y). In very few ejaculated samples or testicular samples, there is not enough spermatozoa for a proper estimation of the risk of aneuploidy.

How should I collect and send the sample?

Different collection and shipment options are available. Please contact Igenomix at info.uk@igenomix.com to decide the most suitable method for you.

Samples must be accompanied by a completed test requisition form.

Documentation

Clinical Sheet

Download

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility specialists worldwide, we investigate human reproduction to change the lives of those who are trying to conceive.

Learn more about Igenomix

Scientific evidence

Relevant related studies:

Title: Impact of different patterns of sperm chromosomal abnormalities on the chromosomal constitution of preimplantation embryos

Authors: Rodrigo L, Peinado V, Mateu E, Remohí J, Pellicer A, Simón C, Gil-Salom M, Rubio C

Publication: Fertil Steril. 2010 Sep;94(4):1380-1386. doi: 10.1016/j.fertnstert.2009.05.061. Epub 2009 Jul 15.

PMID: 19608165

Title: Incidence of sperm chromosomal abnormalities in a risk population: relationship with sperm quality and ICSI outcome

Authors: Rubio C, Gil-Salom M, Simón C, Vidal F, Rodrigo L, Mínguez Y, Remohí J, Pellicer A

Publication: Hum Reprod. 2001 Oct;16(10):2084-92. doi: 10.1093/humrep/16.10.2084.

PMID: 11574496

Title: New tools for embryo selection: comprehensive chromosome screening by array comparative genomic hybridization

Authors: Rodrigo L, Mateu E, Mercader A, Cobo A C, Peinado V, Milán M, Al-Asmar N, Campos-Galindo I, García-Herrero S,Mir P, Simón C, Rubio C

Publication: Biomed Res Int. 2014;2014:517125. doi: 10.1155/2014/517125. Epub 2014 Apr 29.

PMID: 24877108

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility specialists worldwide, we investigate human reproduction to change the lives of those who are trying to conceive.