EndomeTRIO: The endometrium matters

EndomeTRIO
Benefits
Indications

What test does the EndomeTRIO analysis include?

ERA

The ERA test evaluates the receptivity of the endometrium to determine if, at the time of biopsy, the uterine lining is receptive to embryo implantation. This information allows us to determine the ideal time for a personalised embryo transfer (pET). The ERA test resulted in a 73% pregnancy rate in patients with implantation failure.

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ALICE

ALICE (Analysis of Infectious Chronic Endometritis) is a diagnostic test to detect the bacteria causing chronic endometritis (CE), a condition that is associated with infertility.
Independent studies show that this condition affects up to 30% of infertile patients, and in cases of repeated implantation failure or recurrent pregnancy loss, this can rise to 66%*.
ALICE identifies the most common bacteria causing CE and helps clinicians to recommend appropriate antibiotic and probiotic treatments.

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EMMA

EMMA (Endometrial Microbiome Metagenomic Analysis) is a screening test to evaluate the endometrium at the microbiological level, improving clinical management of infertile patients.
By analysing the endometrial microbiome, EMMA determines whether the uterine microbial environment is optimal for embryo implantation.
EMMA provides information about the ten most abundant bacteria in the endometrium, recommending embryo transfer or appropriate treatment, depending on results.

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What is the procedure?

Why does the endometrium matter?

The endometrium has been noted as a key factor for a healthy pregnancy in recent scientific studies. In fact, 20% of infertility is caused by the endometrial factor.

Since 2014, Igenomix has been conducting a deep line of research to understand the role of the endometrial factor in recurrent implantation failure patients.

Our recent publications in the American Journal of Obstetrics and Gynecology (AJOG) demonstrate a new dimension of endometrial health that can improve your patient’s reproductive prognosis.

Why use endomeTRIO test?

A better understanding of endometrial health to improve your patient’s reproductive prognosis: Analyses Endometrial receptivity, chronic endometritis and endometrial flora.
EndomeTRIO uses the latest Next Generation Sequencing technology.

Who should use EndomeTRIO Analysis?

Women who have experienced implantation failure with morphologically good quality embryos
Women with a history of recurrent pregnancy loss
Women with a morphologically normal uterus and normal endometrial thickness (≥ 6 mm), where the physical features of the uterus and endometrium are unlikely to be the problem
Women with Chronic Endometritis

Methodology:

Only a single endometrial biopsy is needed to perform the combined ERA+EMMA+ALICE test, EndomeTRIO.

How should I and send the sample?

An endometrial biopsy taken from the uterine fundus must be immediately place into an ERA cryotube, shaken and stored in a refrigerator (4-8°C/ 39-46°F) for at least 4 hours.
Samples are sent at room temperature(<35ºC/95ºF) accompanied with the patient´s informed consent and a completed requisition form.

Test Limitations

Patients planning an assisted reproduction treatment
ERA test limitations
EMMA test limitations
ALICE test limitations

Documentation

Specialists’ documents

Relevant related studies:

Cicinelli et al. Reprod Sci 2014; 21(5):640-7.

Cicinelli et al. Hum Reprod. 2015; 30(2):323-30.

Moreno I. et tal. Am J Obstet Gynecol, 2018, 218(6):602-602.

Moreno I. et tal. Am J Obstet Gynecol. 2016;215(6):684-703.

Other services

ERA

Evaluates the endometrial receptivity

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EMMA

Evaluates the endometrium at the microbiological level

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ALICE

Detects the bacteria causing chronic endometritis

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EMMA + ALICE + ERA

A better understanding of endometrial health to improve reproductive prognoses

20% of infertility is caused by
the endometrial factor.

What test does the EndomeTRIO analysis include?

ERA