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Genetic Solutions > NACE

NACE Non-invasive prenatal test

Non-invasive prenatal screening helps to avoid unnecessary amniocentesis

  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

Screens for the most common chromosomal abnormalities without risk to your child

Highest informativity rate in the market: we obtain results for 99.9% of the analysed samples

Available from week 10 of pregnancy

Reduces unnecessary amniocentesis

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Or email us at info.uk@igenomix.com
Technical
  • NACE
  • Benefits
  • Indications

What is NACE?

NACE is a non-invasive prenatal screening test for the most frequent chromosomal abnormalities. The test is non-invasive, meaning that there is no risk to the foetus.

A simple blood draw from the mother allows free fetal DNA circulating in the maternal bloodstream to be detected via next-generation sequencing (NGS) technology and our proprietary bioinformatic analysis tool.

Methodology

What does NACE detect?

  • NACE detects abnormalities in chromosomes 13, 18, 21 and the most common anomalies in the sex chromosomes (X and Y).
  • NACE 24 analyzes all chromosomes

NACE can be used for:

  • Single pregnancies
  • Twin pregnancies
  • Can give results with fetal fraction under 4%
  • Natural conception
  • IVF

  • Egg donation
  • Women of all ages
  • Women of all ethnicities
  • Women of all body mass index
  • Suitable for cases of consanguinity

Why use a non-invasive prenatal test

  • Prevent the need for 98% of invasive tests in patients at risk for trisomy 21 (Down syndrome)
  • Reduces the number of miscarriages caused by amniocentesis or chorionic villus sampling (CVS)
  • Can give results with foetal fraction under 4%
  • NACE has the highest informativity rate in the market: we obtain results for 99.9% of the analysed samples
  • More reliable than 1st trimester combined screening. The false positive rates of conventional tests, including biochemical screening, mean that 1 in every 20 women who test positive for Down syndrome will actually be carrying a healthy baby.
  • Avoid a false sense of security: Of every 20 women carrying a baby with Down syndrome, 3 will test negative by biochemical screening.

Who is NACE suitable for?

Several scientific studies support the use of non-invasive prenatal testing for all pregnant women.

  • An abnormal result in their first-trimester screen.
  • A previous Down´s syndrome pregnancy
  • A suspicious ultrasound finding.

(Gregg, et al. Genet Med. 2016)

Test Limitations

  • cfDNA screening is considered a screening test and not a diagnostic test. 
  • False non-invasive prenatal screening (NIPT) results: foetoplacental mosaicism, maternal chromosomal abnormalities, vanishing twin syndrome and/or errors associated with the procedures. 
  • Low-molecular-weight heparin can interfere with the analysis. If the patient is taking heparin during pregnancy, the recommendation is to perform the blood draw before heparin administration. 
Documentation
  • Specialists’ documents

Clinical Sheets

Download
Scientific evidence

Relevant related studies:

Title: Fetal sex determination in twin pregnancies using cell free fetal DNA analysis

Authors: Milan M, Mateu E, Blesa D, Clemente-Ciscar M, Simon C

Publication: Prenat Diagn. 2018 Apr 23. doi: 10.1002/pd.5274.

PMID: 29683524

Title: Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics

Authors: Gregg A R, Skotko B G, Benkendorf J L, Monaghan K G, Bajaj K, Best R G, Klugman S, Watson M S

Publication: Genet Med. 2016 Oct;18(10):1056-65. doi: 10.1038/gim.2016.97. Epub 2016 Jul 28.

PMID: 27467454

Title: DNA sequencing versus standard prenatal aneuploidy screening

Authors: Bianchi D W, Parker R L, Wentworth J, Madankumar R, Saffer C, Das A F, Craig J A, Chudova D I, Devers P L, Jones K W, Oliver K, Rava R P, Sehnert A J, CARE Study Group

Publication: N Engl J Med. 2014 Feb 27;370(9):799-808. doi: 10.1056/NEJMoa1311037.

PMID: 24571752

Title: Screening for fetal aneuploidies at 11 to 13 weeks

Author: Nicolaides K H

Publication: Prenat Diagn. 2011 Jan;31(1):7-15. doi: 10.1002/pd.2637.

PMID: 21210475

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