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Genetic Solutions > NACE

NACE Non-invasive prenatal test

Non-invasive prenatal screening helps to avoid unnecessary amniocentesis

  • Technical Overview
  • Documentation
  • Scientific evidence
  • I’m not a health specialist

Screens for the most common chromosomal abnormalities without risk to your child

Highest informativity rate in the market: we obtain results for 99.9% of the analyzed samples

Available from week 10 of pregnancy

Reduces unnecessary amniocentesis

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Technical
  • NACE
  • Benefits
  • Indications

What is NACE?

NACE is a non-invasive prenatal screening test for the most frequent chromosomal abnormalities. The test is non-invasive, meaning that there is no risk to the fetus.

A simple blood draw from the mother allows free fetal DNA circulating in the maternal bloodstream to be detected via next-generation sequencing (NGS) technology and our proprietary bioinformatic analysis tool.

Methodology

What does NACE detect?

  • NACE detects abnormalities in chromosomes 21, 18, 13 and the most common anomalies in the sexual chromosomes (X and Y).
  • NACE 24 analyzes all chromosomes
  • NACE 24 Extended analyzes all 24 chromosomes and identifies microdeletions associated with 6 major genetic syndromes.

NACE can be used for:

  • Single pregnancies
  • Twin pregnancies
  • Can give results with fetal fraction under 4%
  • Natural conception
  • IVF
  • Egg donation
  • Women of all ages
  • Women of all ethnicities
  • Women of all body mass index
  • Suitable for cases of consanguinity

Why use a non-invasive prenatal test

  • Prevent the need for 98% of invasive tests in patients at risk for trisomy 21 (Down Syndrome)
  • Reduces the number of miscarriages caused by amniocentesis or chorionic villus sampling (CVS)
  • Can give results with fetal fraction under 4%
  • NACE has the highest informativity rate in the market: we obtain results for 99.9% of the analyzed samples
  • NACE Extended 24 incorporates the detection of all 24 chromosomes and identifies five microdeletions that are associated with major genetic syndromes
  • More reliable than 1st trimester combined screening. The false positive rates of conventional tests, including biochemical screening, mean that 1 in every 20 women who test positive for Down syndrome will actually be carrying a healthy baby.
  • Avoid a false sense of security: Of every 20 women carrying a baby with Down syndrome, 3 will test negative by biochemical screening.

Who is NACE suitable for?

Several scientific studies support the use of non-invasive prenatal testing for all pregnant women.

  • An abnormal result in their first-trimester screen.
  • A previous Down´s syndrome pregnancy
  • A suspicious ultrasound finding.

(Gregg, et al. Genet Med. 2016)

Test Limitations

  • cfDNA screening is considered a screening test and not a diagnostic test. 
  • False non-invasive prenatal screening (NIPT) results: fetoplacental mosaicism, maternal chromosomal abnormalities, vanishing twin syndrome and/or errors associated with the procedures. 
  • Low-molecular-weight heparin can interfere with the analysis. If the patient is taking heparin during pregnancy, the recommendation is to perform the blood draw before heparin administration. 
Documentation
  • Specialists’ documents

Clinical Sheets

Download
Scientific evidence

Relevant related studies:

Milan M, Mateu E, Blesa D, Clemente-Ciscar M, Simon C. Fetal sex determination in twin pregnancies using cell free fetal DNA analysis. Prenat Diagn. 2018 Apr 23.

Gregg AR et al. Genet Med 2016; 18:1056-65.

Bianchi et al. N Engl J Med. 2014 27;270 (9):799-808.

Nicolaides KH. Prenat Diagn 2011; 31:7-15-

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