ERA® Endometrial Receptivity Analysis

Overview

ERA
Benefits
Indications

What is the ERA test?

The Endometrial Receptivity Analysis (ERA), developed and patented by Igenomix (PCT/ ES2009/000386), is a test designed to evaluate endometrial receptivity.
The ERA test has been shown to be highly sensitive and specific in the detection of genetic expression profiles associated with receptivity. It allows a patient’s personalized window of implantation to be detected and applied to their future frozen embryo transfers.

What is the procedure?

Why use ERA test?

This molecular diagnostic tool uses NGS to analyze the expression level of 248 genes related to the status of endometrial receptivity.
The ERA test resulted in a 73% pregnancy rate in patients with implantation failure.
ERA is backed by 33 publications; 29 from Igenomix and 4 external publications.
Proprietary algorithm based on machine learning that minimizes the need for second biopsy (90% of cases).
Allows clinicians to identify transition phases with 12 hours shifts.

Who should use ERA test?

Women who have experienced implantation failure with morphologically good quality embryos
Women with a morphologically normal uterus and normal endometrial thickness (≥ 6 mm), where the structure of the uterus and endometrium are unlikely to be the problem.

When is the second endometrial biopsy needed?

90 % of cases don’t need a second biopsy. The second biopsy is only required under two circumstances:

Patients with a “Pre-receptive 2 days” result
Patients with a “Post-receptive” result

Test limitations

There is a risk (<5%) of a non-informative result when the biopsy procedure has failed to obtain a sufficient quantity and/or quality of tissue to be able to make a diagnosis. If this should occur a new biopsy will be required.
The aim of this test Is to provide physicians with an objective molecular diagnosis of the patient’s endometrial receptivity window. Depending on the results of this test, the physician may use it as a guide for a personalised embryo transfer.
Pregnancy is not guaranteed, even with a receptive result. Poor embryo quality, genetic abnormalities, or previous pathologies can also reduce the likelihood of becoming pregnant.
ERA® does not test for any other endometrial pathology and does not asses or provide a prediction for the health of a subsequent pregnancy.

Documentation

ERA Specialist's documents

The development of the ERA diagnostic tool was published in the paper by Díaz-Gimeno et al, 2011 (Fertil Steril. 2013 Feb; 99(2):508-17).

ERA´s effectiveness and consistency were demonstrated in the paper by Díaz-Gimeno et al, 2013 (Fertil Steril. 2013 Feb; 99 (2): 508-17).

ERA clinical applicability to patients with implantations failure was demonstrated in a publication by Ruiz-Alonso et al, 2013 and 2014.

What a difference two days make: “personalized” embryo transfer (pET) paradigm: a case report and pilot study Ruiz-Alonso M. et al, 2014. (Hum Reprod. 2014 Jun;29(6):1244-7)

A randomized study is currently in progress to assess its applicability to patients without any prior assisted reproduction treatment (ClinicalTrials.gov Identifier: NCT01954758).

The role of the endometrial receptivity array (ERA) in patients who have failed euploid embryo transfers. Tan J, Kan A, Hitkari J, Taylor B, Tallon N, Warraich G, Yuzpe A, Nakhuda G. J Assist Reprod Genet. 2018 Jan 11. doi: 10.1007/s10815-017-1112-2. [Epub ahead of print]

Combinatorial use of Endometrial Receptivity Array (ERA) and PGT-A can improve the clinical outcome in cases with previous ART failures. N. Findikli, M. Gultomruk, K. Boynukalin, M. Kavrut, E. Oral, M. Bahceci. ESHRE Oral communication.

Pregnancy outcomes in patients undergoing embryo transfer in cycle following endometrial receptivity assay. M. Pasternak, G. Schattman, Z. Rosenwaks. ASRM Poster.

The implantation rate of Japanese infertile patients with repeated implantation failure can be improved by endometrial receptivity array (ERA) test: A randomized controlled trial. S. Taguchi, M. Funabiki, T. Hayashi, Y. Tada, Y. Iwaki, M. Karita, T. Ota, K. Maeda, T. Matsubara, P. Zada, N. Sugiyama, Y. Nakamura. ASRM Oral communication.

Efficacy of the endometrial receptivity array for repeated implantation failure in Japan: A retrospective, two-centers study. Hashimoto T, Koizumi M, Doshida M, Toya M, Sagara E, Oka N, Nakajo Y, Aono N, Igarashi H, Kyono K. Reprod Med Biol. 2017 Jun 27;16(3):290-296. doi: 10.1002/rmb2.12041. eCollection 2017 Jul. PMID:29259480

Assessment of endometrial receptivity by endometrial receptivity array (ERA) in patients with adenomyosis and previous implantation failure in IVF. Kaur S, Mahajan N, Rani K, Naidu P, Kaur J. ESHRE Poster.

Mode of progesterone administration and its effects on endometrial receptivity in programmed frozen embryo transfer cycles. Rosen A, Huang A, Billb Y. PCRS Poster.

Endometrial Receptivity and pregnancy rates are higher after 7 days of progesterone in medicated FET cycles. A.M. Propst, L. Hansard, K. Silverberg, M. Hegtvedt, N.Z. Burger, T.C. Vaughn. ASRM Poster.

Endometrial receptivity array: Clinical application. Mahajan N. J Hum Reprod Sci. 2015 Jul-Sep;8(3):121-9. doi: 10.4103/0974-1208.165153. Review. PMID:26538853.

Live birth after embryo transfer in an unresponsive thin endometrium. F. Cruz, J. Bellver. Gynecol Endocrinol. 2014 Jul;30(7):481-4. doi: 10.3109/09513590.2014.900747. Epub 2014 Mar 20.

Mode of progesterone administration and its effects on endometrial receptivity in programmed frozen embryo transfer cycles. Rosen A, Huang A, Billb Y. PCRS Poster.

If you're a little lost with this technical information...

Can we help you?

I’m not a health specialist

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility specialists worldwide, we investigate human reproduction to change the lives of those who are trying to conceive.

Learn more about Igenomix

Other services you may be interested in

EndomeTRIO

A new dimension of endometrial health

More information

EMMA

Evaluates the endometrium at the microbiological level

More information

ALICE

Detects the bacteria causing chronic endometritis

More information

Robust randomized clinical study results

Supported by 33 publications

30% of patients have a displaced window of implantation

55.000 patients

Are you interested?

What is the ERA test?

What is the procedure?

Why use ERA test?

Who should use ERA test?

When is the second endometrial biopsy needed?

Test limitations

Technical Sheets

Brochure

Relevant related studies:

Can we help you?

Igenomix and fertility

Learn about genetics

NEW COURSES AVAILABLE:

Non Invasive PGS, Maria Vera

EndomeTRIO

EMMA

ALICE

ERA® Endometrial Receptivity Analysis

The ERA test evaluates the receptivity of the endometrium to determine if, at the time of biopsy, the uterine lining is receptive to embryo implantation. This information allows us to determine the ideal time for a personalised embryo transfer (pET).

Robust randomized clinical study results

Supported by 33 publications

30% of patients have a displaced window of implantation

55.000 patients

Are you interested?

What is the ERA test?

What is the procedure?

Why use ERA test?

Who should use ERA test?

When is the second endometrial biopsy needed?

Test limitations

Technical Sheets

Brochure

Relevant related studies:

Can we help you?

Igenomix and fertility

Learn about genetics

NEW COURSES AVAILABLE:

Non Invasive PGS, Maria Vera

Other services you may be interested in

EndomeTRIO

EMMA

ALICE

Igenomix is in the media