ALICE Analysis of Infectious Chronic Endometritis

Genetic Solutions > ALICE

Overview

ALICE
Indications
Benefits

What is ALICE test?

ALICE is a test that detects pathogenic bacteria and recommends adequate treatment.

Pathogenic bacteria cause chronic endometritis, which is linked to implantation failure and recurrent miscarriage.

In cases of repeated implantation failure or recurrent pregnancy loss, chronic endometritis can rise to 66%.

What is the procedure?

ALICE can be performed on a small piece of an endometrial biopsy.

Who should use ALICE?

ALICE may be beneficial for patients with a history of recurrent pregnancy loss or recurrent implantation failure because chronic endometritis has been linked to these events.

Test limitations

This test is not able to detect resistance to antibiotics.
ALICE only detects the presence of pathogens associated with Chronic Endometritis. A negative result doesn’t rule outthe presence of other endometrial pathogens.

Why use ALICE?

ALICE is a diagnostic test to detect and quantify the most common pathogenic bacteria causing chronic endometritis, recommending appropriate antibiotic and probiotic treatment
If the ALICE test is positive, the report will focus on the detection of the specific bacteria causing the condition
A list with the recommended antibiotics and probiotics will be provided depending on ALICE results
Microbiology counselling is available

Documentation and Resources

ALICE Specialists' documents

Authors: Moreno I, Garcia-Grau I, Perez-Villaroya D, Gonzalez-Monfort M, Bahçeci M, Barrionuevo M. J, Taguchi S, Puente E, Dimattina M, Lim M. W, Meneghini G, Aubuchon M, Leondires M, Izquierdo A, Perez-Olgiati M., Chavez A., Seethram K., Bau D., Gomez C., Valbuena D, Vilella F, Simon C

Publication: Microbiome. 2022 Jan 4;10(1):1. doi: 10.1186/s40168-021-01184-w.

PMID: 34980280

Title: Human Microbiome Project Consortium – Structure, function and diversity of the healthy human microbiome

Authors: Human Microbiome Project Consortium

Publication: Nature. 2012 Jun 13;486(7402):207-14. doi: 10.1038/nature11234.

PMID: 22699609

Title: Evidence that the endometrial microbiota has an effect on implantation success or failure

Authors: Moreno I, Codoñer F, Vilella F, Valbuena D, Martinez-Blanch J F, Jimenez-Almazán J, Alonso R, Alamá P, Remohí J, Pellicer A, Ramon D, Simon C

Publication: Am J Obstet Gynecol. 2016 Dec;215(6):684-703. doi: 10.1016/j.ajog.2016.09.075. Epub 2016 Oct 4.

PMID: 27717732

Title: The diagnosis of chronic endometritis in infertile asymptomatic women: a comparative study of histology, microbial cultures, hysteroscopy, and molecular microbiology

Authors: Moreno I, Cicinelli E, Garcia-Grau I, Gonzalez-Monfort M, Bau D, Vilella F, De Ziegler D, Resta L, Valbuena D, Simon C

Publication: Am J Obstet Gynecol. 2018 Jun;218(6):602.e1-602.e16. doi: 10.1016/j.ajog.2018.02.012. Epub 2018 Feb 23.

PMID: 29477653

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