Embryo Developmental Arrest (EDA) is one of the mechanisms responsible for an increased level of embryo demise during the first week of in vitro development. Around 10-15% embryos permanently arrest in mitosis at the 2-to 4-cell cleavage stage. It involves the downregulation and/or cessation of cell division and metabolic activity of the components involved in the formation and development of an embryo. Chromosomal abnormalities, abnormal preimplantation development and single gene disorders have been stated as causes of EDA and therefore, a known cause of infertility. The identification of abnormal gene changes previously known to have an effect on embryo development is crucial to improve pregnancy outcomes.
The Igenomix Embryo Developmental Arrest Precision Panel can be used to make a directed and accurate differential diagnosis of inability to carry out a full pregnancy ultimately leading to a better management and achieve a healthy baby at home. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes involved.
The clinical utility of this panel is:
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