Oligohydramnios is defined as an abnormally low volume of amniotic fluid. Amniotic fluid is crucial for fetal development and growth, serving as protection to the fetus from trauma and infection as well as helping in the development of the fetal lungs. Normal amniotic fluid varies, on average it can reach up to 800-1000mL. An excess of amniotic fluid is termed polyhydramnios, decreased amniotic fluid is oligohydramnios. It occurs in approximately 11% of all pregnancies. Causes of oligohydramnios include rupture of membranes, fetal urinary tract blockage (renal agenesis, posterior urethral valves or polycystic kidney disease) which can have a genetic background associated with other genetic conditions. The mortality is high, especially if it is diagnosed during the first trimester as it can increase the risk for chest wall fixation and pulmonary hypoplasia.
The Igenomix Oligohydramnios Precision Panel can be used to make a directed and accurate differential diagnosis of oligohydramnios and uncover the genetics underlying this clinical sign ultimately leading to a better management and achieve a healthy baby at home. It provides a comprehensive analysis of the genes involved in this disease using next-generation sequencing (NGS) to fully understand the spectrum of relevant genes involved.
The clinical utility of this panel is:
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