POC Products of Conception

POC
Benefits
Indications

What is POC?

The POC test analyzes fetal tissues from a miscarriage to determine if the lost pregnancy was the result of a chromosomal aneuploidy.

This test can provide you an important information about the possible causes of your patient’s miscarriage to help them to plan any future pregnancy..

Methodology

How to collect and send the sample

If a conventional curettage method is used, the sample should be collected in a sterile container and covered with saline, taking care to avoid contamination with maternal tissue as far as possible. The sample can also be obtained by directed biopsy following hystero-embryoscopy, and placed in a sterile 10 ml conical tube containing saline. 5 ml of maternal blood should be collected in an EDTA tube. Send the sample in the sealed container and maternal blood at room temperature and with suitable packaging to prevent damage. The sample should be sent as soon as possible to prevent tissue degradation. If there is a delay in sending the sample and blood, they should be refrigerated at 4ºC.

Why use POC test?

The genetic study of fetal tissue is a valuable tool to determine the cause of the miscarriage, which enables appropriate reproductive counseling for the couple.

Results are obtained in 99% of cases.
Results are available in 10 working days as cell culture is not required.
24 chromosomes are screened to identify the reason for miscarriage.
Can be performed on twin pregnancies.
Our test discerns between maternal and fetal tissue using DNA fingerprinting (STR Technology).
NGS has higher resolution than a conventional karyotype.

Who should use POC test?

POC is recommended for all couples who have suffered a miscarriage, but is essential for couples who have experienced recurring spontaneous abortions and those undergoing assisted reproduction treatments.

Test Limitations

This technique does not detect balanced structural chromosomal abnormalities and may not detect: low-level mosaic aneuploidy, triploid/tetraploid chromosomes, uniparental disomy, deletions or duplications under 10 Mb.

Documentation

Authors: Campos-Galindo I, García-Herrero S, Martínez-Conejero J A, Ferro J, Simón C, Rubio C

Publication: J Assist Reprod Genet. 2015 May;32(5):839-48. doi: 10.1007/s10815-015-0460-z. Epub 2015 Mar 17.

PMID: 25779005

Title: Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment

Authors: Martínez M C, Méndez C, Ferro J, Nicolás M, Serra V, Landeras J

Publication: Fertil Steril. 2010 Jan;93(1):289-92. doi: 10.1016/j.fertnstert.2009.07.989. Epub 2009 Sep 11.

PMID: 19748088

Igenomix and fertility

We work to make a world in which infertility is no longer an impossible barrier. Together with clinics and fertility specialists worldwide, we investigate human reproduction to change the lives of those who are trying to conceive.